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KMID : 0644120090220020079
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Journal of Oriental Gynecology
2009 Volume.22 No. 2 p.79 ~ p.93
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Fermented Artemisiae Argyi Folium and Epimedii Herba Mixture Effect on Macrophage’ Activity
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Ryu Hahn-Woo
Kim Yun-Sang
Lim Eun-Mee
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Abstract
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Purpose: This research aimed to study the effect of FAE(Ferment Artemisiae Argyi Folium and Epimedii Herba) on the mouse macrophage cell activity.
Methods: Effect of FAE, which was fermented by Sacchromyces cerevisiae STV89, on cell viability, amount of within cells, amount of NO was measured and compaperd by using mouse macrophage cells.
Results: 1. Result of MTT assay conducted to observe the effect of FAE on the survival rate of mouse macrophage cells illustrated that, when FAE was proccessed for each concentration, there was no significant decrease of the survival rate. 2. FAE increased the amount of within macrophage cells and increased inhibition of amount of in macrophage induced by LPS. 3. FAE inhibited amount of NO in macrophage cells, and significantly inhibited increase of amount of NO in mcacrophage induced by LPS.
Conclusion: FAE produced by Artemisiae Argyi Folium and Epimedii Herba did not induce the decrease of macrophage cell survival rate, increased amount of within cells, and reduced amount of NO. FAE significantly increase by LPS, reduced the increase of amount of NO in macrophage induced by LPS. These results signify FAE has significant effect on immuno modulating activity of macrophage.
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KEYWORD
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Artemisiae Argyi Folium, Epimedii Herba, Fermented Herbal Medicine, Macrophage, Immuno activity
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